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had a serum calcitonin level (at visit 1) of 20 ng l 1 , if eGFR 60 ml min 1 1.73 m 2 35 ng l 1 , if eGFR 2 weeks or 14 days) systemic glucocorticoid therapy (excluding topical, intraocular, intranasal, intra-articular or inhaled preparations) or had evidence of a substantial, active autoimmune abnormality (for example, lupus or rheumatoid arthritis) that had required (within the past 3 months) or was likely to require, in the opinion of the investigator, concurrent treatment with systemic glucocorticoids (excluding topical, intraocular, intranasal, intra-articular or inhaled preparations) during the course of the study 33
When you plot this, several patterns emerge
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Rybelsus is the first oral GLP-1 receptor agonist and requires specific administration: it must be taken on an empty stomach with up to 120ml of water, swallowed whole, and followed by at least 30 minutes before eating, drinking or taking other oral medications
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