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The cationic amino acid transporter-2 (CAT-2) mediates arginine uptake, which is required for arginase activity and subsequent collagen production, particularly in macrophages [74]

This epigenetic action is supported by findings showing Epitalons capacity to penetrate cell nuclei and influence chromatin structure, making telomerase genes more accessible for activation

DADS and DATS inhibited the expression of adhesion molecules, E-selectin and vascular cell adhesion molecule-1 (VCAM-1), on endothelial cell surface by reversing oxidized LDL-induced inhibition of PI3K/Akt and cAMP responsive element binding protein (CREB) signaling pathways (50)

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