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GLP-1 analogs indirectly impact hepatic metabolism via its direct effects on the pancreas and central nervous system

Generation of KO and knockdown cell lines Optimized sgRNA oligonucleotides 64 were cloned into lentiCRISPRv2 (ref

An individualized approach considering medical history, current health status, and treatment goals is essential for the best outcomes

All authors contributed to the interpretation of the data, critically revised the manuscript, provided intellectual input and approved the final version to be published

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The study concludes semaglutide has significantly greater efficacy than liraglutide when combined with a healthy lifestyle and increased physical activity