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Indeed, the association of doxorubicin with bioenergetic toxicity is well stated in the literature 32,33,34

Testicular MDA, and glutathione content, catalase activity and expression of genes involved in oxidative stress were not significantly affected by the HFD feeding protocol in the current study

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Smith A, McCulloh RJ

In line with the covalent binding mechanism, in vitro and cell-based thermal-shift assays showed that C1-27 induced a negative shift in the melting temperature indicating protein destabilization on binding (Supplementary Figs 11 and 15)

doi: 10.1016/j.pharmthera.2018.10.012 108 aoCLiuXZhangYLeiGYanYLeeHet al