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Innovation opportunities span oral bioavailability enhancers, ultra-long-acting injectables that may halve injection frequency, and fixed-dose combinations pairing semaglutide with SGLT-2 inhibitors or amylin analogs

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Patients on the drug saw their retinopathy temporarily worsen, an effect investigators attributed to blood sugar dropping too fast

[1] [2] The primary mechanism involves gastrointestinal effects and reduced oral intake