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Bariatric surgery has decades of long-term research showing sustained weight loss, while the long-term effects of GLP-1 medications are still being studied.

However, retatrutide is not yet licensed in the UK and these findings require confirmation in larger, longer-term studies

Cardiovascular disease is a leading cause of deaths worldwide, accounting for 15-17% of healthcare costs

Where it tends to fall short is when it is treated as a quick fix

This latter reaction is the only PLP-dependent process that is not associated with metabolism of nitrogen containing compounds (principally amino acids)