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Pancreatic Insufficiency: The pancreas helps with B12 absorption, and not enough of it can cause deficiency

summary Some animal studies suggest that a deficiency in vitamin B12 may increase body fat percentage and alter metabolism

While anecdotal reports and some preliminary research suggest that it may aid in weight reduction by promoting gut health and improving metabolic function, there is currently insufficient scientific evidence to validate these claims fully

In gastrointestinal research, a 2017 rat colitis and ischemia-reperfusion study by Duzel and colleagues in World Journal of Gastroenterology reported that a single 10 g/kg topical bath of BPC-157 to blood-deprived colon segments produced near-complete mucosal preservation by day 10, restored vessel-arcade interconnections, and normalized MDA and NO levels relative to saline controls though the abstract does not report numeric % lesion reduction or p-values

Similarly, a pilot study in 2015, a clinical trial (randomised) on 42 healthy human participants, receiving oral (tablet form) dosages of BPC 157 was carried out (Clinicaltrials.gov 2018): 0.25, 0.5, 1 and 2 g/kg

& Charlson, R