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Primary bone marrow derived mast cells treated with up to 100 M of formonetin showed no cytotoxicity, but reduction in degranulation (IC 50 = 50.24 M) and TNF- and IL-13 mRNA expression (10, 20, 40 M)
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This upregulation could theoretically result in enhanced telomere maintenance and extended cellular replicative capacity
Similarly, metoclopramide is restricted to short-term use (maximum 5 days) due to risk of neurological side effects
209 Additionally, the potential neuroprotective effects of tirzepatide remain unclear
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