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The age-related efficacy of FOXO4-DRI has also been a point of debate

Cancer J (Sudbury, Mass.) 20(3):170 Hwang JS, Hwang JS, Chang I, Kim S (2007) Age-associated decrease in proteasome content and activities in human dermal fibroblasts: restoration of normal level of proteasome subunits reduces aging markers in fibroblasts from elderly persons

2 We know that the gene coding for the Class 1 MHC molecule, HLAB27, is found in more than 90% of Caucasians with AS, and that bacteria in the gastrointestinal tract in some poorly defined way, play a role in the pathogenesis of this disorder

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