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Furthermore, within the context of cardiovascular disease (CVD), the aging of the cardiovascular system plays a crucial role as a contributing factor

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Pregnancy or actively trying to conceive : these medications are not studied in pregnant women and must be discontinued at least 2 months before conception

Example Gain-of-Function A number of endocrine diseases are caused by gain-of-function mutations of GPCRs

doi: 10.1016/S0140-6736(18)30726-8 83 EngJKleinmanWASinghLSinghGRaufmanJP

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