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Bacteria can enter the vial through the rubber stopper, and in a nutrient-rich peptide solution, they can multiply rapidly at room temperature

The pathological mechanisms underlying DR are complex and involve multiple interrelated processes, including metabolic, inflammatory, and neurodegenerative pathways

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Furthermore, this complex is reversibly inactivated by the phosphorylation of the -subunit of the complex, which catalyzes the rate-limiting reaction of the oxidative decarboxylation of pyruvate ( The acetyl-CoA produced from glucose or other substrates, such as lactate, ketone bodies or medium chain fatty acids (Zhang et al., 2015), condenses with oxaloacetate and enters the TCA cycle as citrate ( 2 for the oxidative phosphorylation pathway ( Complete oxidation of a molecule of glucose occurs in the mitochondria by the electron transport chain, whereby the high-energy metabolites NADH and FADH 2 donate electrons to electron acceptors and finally oxygen via a series of redox reactions

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