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Their muscle-to-fat ratio usually still improves, but in particularly vulnerable populations, such as older adults, rapid and significant muscle loss can be a dangerous issue

Patients unconsciously breathe shallowly to avoid discomfort, which can trigger tension in the serratus anterior, thoracic spine muscles, and diaphragm

Developed by Eli Lilly under the code LY3437943, retatrutide has now progressed through Phase 3 clinical trials with landmark results published between December 2025 and May 2026, positioning it as one of the most closely watched metabolic research compounds in modern pharmacology

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This can create a self-reinforcing cycle of increased neurotoxicity (133)