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5.2 Animals In accordance with 3R principles, most samples analyzed in this study for IHC-based quantification of intestinal cells were obtained from our tissue biobank and generated in the context of previously published studies (9, 3638, 102)

NMR Structural Resolution of FOXO4-DRI/p53TAD2 Complex (Nature Communications, 2025) Disordered-to-Ordered Complex Formation: Structural Basis of FOXO4-DRIs Senolytic Mechanism A landmark structural study published in Nature Communications (2025) resolved the solution NMR structural models of the p53 transactivation domain (TAD2) in complex with the FOXO4 forkhead domain and with FOXO4-DRI

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These results represent a major advance, as no pharmacological therapy has previously demonstrated such consistent improvements in histological endpoints for NASH

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