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Owing to the differences in biology and disease progression between rodents and humans, along with the complexity of human neurodegenerative diseases, results obtained from experimental models must be interpreted with caution [233]

Beyond sleep, DSIP research has revealed potential applications in pain management (showing analgesic effects when administered intracerebroventricularly), addiction treatment (alleviating withdrawal symptoms in 97% of opiate-dependent and 87% of alcohol-dependent patients in one trial), antioxidant defense, and even stroke recovery