Approved indications Tresiba is approved for type 1 diabetes and type 2 diabetes
Insurance coverage for brand-name medications like Ozempic and Wegovy is challenging for many patients as it requires a valid prescription for the FDA-approved indication of the medication, prior authorization, and extensive criteria to fulfill
3,5 In early T2DM managed with lifestyle alone, orforglipron lowered glycated hemoglobin A1c (HbA1c) by -1.24 to -1.48 percentage points over 40 weeks as compared to -0.41 with placebo, with no severe hypoglycemia reported and weight reduction ranging from 4.5% to 7.6%, 3 which led to mean HbA1c levels of 6.5-6.7%
Due to their effectiveness, GLP-1-based medicines have become fundamental in obesity pharmacotherapy, with current investigations into next-generation multi-agonists (e.g., retatrutide) aimed at improving results [39]
Though remarkably effective, bariatric surgery carries the limitations inherent to any invasive procedure (surgical complications, cost, access): it is hard to imagine tens of millions of obese individuals going under the knife each year
S., Shapiro, J., & Lo Sicco, K