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10.1016/j.brainresbull.2014.04.011 Brain Res

2) Can metabolic improvement itself attenuate craving and reinforcement

Zepbound's peptide structure enables it to activate both GIP and GLP-1 receptors simultaneously, unlike single-receptor GLP-1 agonists such as semaglutide

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Those are covered at the end of this article

However, tirzepatide takes a dual approach by stimulating both GLP-1 and GIP receptors simultaneously, creating a more comprehensive hormonal response that amplifies appetite suppression and increases energy expenditure