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Semaglutide Genetic variations in GLP-1 receptor sensitivity, GIPR signaling capacity, and appetite-regulation pathways significantly influence whether a patient responds better to semaglutide monotherapy or tirzepatide's dual-receptor approach

Compared with people taking the placebo, those on tirzepatide were able to walk farther and reported higher scores on a questionnaire that gauged how they were feeling

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doi:10.1113/jphysiol.2012.244897 Paddon-Jones D, Sheffield-Moore M, Katsanos CS, et al