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The accumulation of metabolic waste products and alterations in pH can further contribute to a hostile TME, which can impair immune function and promote tumor progression

Freezing can rupture the protein structure and make it useless

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40 Insulin receptor is expressed in skeletal muscle, adipocytes, kidneys, brain, blood vessels, heart, liver, pancreatic endocrine cells (such as islet alpha and beta-cells), bone and the GIT