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TGF beta mediates activation of transglutaminase 2 in response to oxidative stress that leads to protein aggregation
(Chen, 2019)
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At doses of 7 mg and 14 mg per day, it is approved as an adjunct to diet and exercise to improve glycaemic control in adults with type 2 diabetes, and to reduce the risk of major adverse cardiovascular events in adults with that condition who are at high cardiovascular risk
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