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These discrepancies may result from different experimental animals, the CKD stage, diet composition, and varied participant baseline characteristics (Yokoyama et al., 2012

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However, it often fails to resolve the symptoms due to varied reasons such as poor adherence to therapy, low inspiratory flow, reduced dexterity due to multiple comorbidities, physical disability, age, injury, cognitive impairment, and errors in the use of inhalers