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Topical growth factor preparations for facial skin rejuvenation: A systematic review
The N-terminal segment (residues 113) penetrates deeply into the receptor transmembrane domain core, while the C-terminal segment (residues 1430) interacts with the extracellular domain, the extracellular end of TM1, and ECL1
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However, years later in 2016, a pharmacological analysis of this ligand demonstrated interspecies differences between the rodent and human GIP system and also led to the conclusion that the human Pro3(GIP) was a potent partial agonist with the ability to activate the human GIP receptor with a maximal efficiency (E max ) of 90% compared to human GIP (68)
