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Updated on July 23rd, 2026

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Melatonin is synthesized in the pineal gland through the activation of two key enzymes: AANAT (arylalkylamine N-acetyltransferase) pCREB (phosphorylated cAMP response element-binding protein) In rat pinealocytes, Epitalon was shown to upregulate both AANAT and pCREB, suggesting a direct enzymatic stimulation of melatonin biosynthesis [56]

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They are called free because they drift around the body with at least one unpaired electron in its outermost shell until they stabilize, and radical because there is a large compilation of molecules from which they can snatch electrons from