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The increased estrogen levels can act on the pituitary gland and trigger a negative-feedback loop suppressing the HPG axis and reducing T levels [13]

Increased levels of oxidative stress have consistently been found in both ME/CFS and fibromyalgia

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The article says rare but serious events including acute pancreatitis, thyroid concerns, and gallbladder complications have been reported outside controlled settings, and that the follow-up in published trials does not stretch far enough to settle the longest-term questions

It received FDA approval on August 22, 2008

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