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Functionally, zone 1 hepatocytes are specialized for oxidative liver functions such as gluconeogenesis, b-oxidation of fatty acids, and cholesterol synthesis, while zone 3 cells are more important for glycolysis, lipogenesis, and cytochrome P-450based drug detoxification

Pharmaceuticals (Basel) 2022, 15(6)

Dehydration from gastrointestinal side effects may cause elevated creatinine or blood urea nitrogen, necessitating hydration counseling and possible dose adjustment

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Always report symptoms to your healthcare provider

In vitro experiments found compound 31 (Figure 5) to be the most potent, as predicted by in-silico simulations, with an IC 50 of 3.16 M