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C., Stefanski, A., & Tirzepatide Once Weekly for the Treatment of Obesity Investigators

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This enforcement reinforces the principle that the regulatory and scientific rigor underlying drug approvalincluding demonstrated bioequivalence, current good manufacturing practice (cGMP) compliance, and ongoing postmarket safety reportingcannot be substituted by marketing language alone

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Coskun and colleagues (Cell Metabolism, 2022) provided the foundational characterisation, demonstrating that balanced engagement of all three receptors produces metabolic effects not achievable through dual or single-receptor pharmacology alone

Do not test it