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First cardiovascular safety trial to demonstrate that a GLP-1R agonist reduces MACE and microvascular (including renal) events in patients with T2DM and high cardiovascular risk

However, combination protocols lack controlled clinical trials, and safety/efficacy data comes primarily from preclinical research and anecdotal reports

A B12 deficiency can cause a surprisingly wide range of bizarre symptoms beyond just feeling tired

The BMC Medicine paper further noted that participants who lacked structured behavioral support were significantly more likely to regain weight

JAMA Internal Medicine , 180 (9), 11731184