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Nevertheless, the use of nanomedicine in TNBC is restricted by the lack of ligands and a known highly expressed tumour target
Oxidized PAC-quinone imine metabolites have also been shown to form GSH-conjugates which inhibit glutathione reductase (GR): the decreased activity of GR hampers the detoxification and antioxidant capacity of the GSH-GSSG cycle, further aggravating the pro-oxidative status in the cell (Ndlov et al., 2014)
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They also have dozens of benefits and few rare side-effects
Mutations in the SLC6A4 gene affect the rate of serotonin re-uptake and have been shown to be correlated with obsessive-compulsive disorder, anxiety-related traits, and are suspected to be involved in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in persons experiencing emotional trauma
While increased ROS production can also be detrimental to the plant, at subtoxic doses, sulforaphane also activates the plants host defense mechanisms by inducing expression of stress response genes, such as heat shock proteins (Ferber et al., 2020)
