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Researchers synthesized several aryl acetic acid conjugates and evaluated their anti-inflammatory potential in LPS-stimulated BV-2 microglial cells and primary murine microglial cells (107)
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GCase activity is correlated with increased neuroinflammation, -syn aggregation, and neurodegeneration [159,160,161]
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These signaling events are commonly assessed using enzyme activity assays, phosphorylation analysis, and gene expression profiling in laboratory systems