Specifically, NICE suggests considering a DPP-4 inhibitor as a second agent when: The patient has a high risk of hypoglycaemia (making sulfonylureas less suitable) Weight management is a concern and a sulfonylurea's weight-gaining effects are undesirable An SGLT-2 inhibitor is contraindicated or not tolerated NICE NG28 recommends that in patients with established atherosclerotic cardiovascular disease, heart failure, or chronic kidney disease, an SGLT-2 inhibitor should generally be prioritised often alongside or instead of metformin due to its organ-protective benefits
Foremost, it is up to a doctor and their differential diagnoses based on your health history and pre-existing conditions, bloodwork, and body mass index
It is also virtually calorie free, with just 10% of the calories of sugar, making it a great tool for weight management
See the best dosage for different uses, such as lowering triglyceride levels or improving mood, plus information on overdose
The downside is that nausea may be more noticeable during your work or daily activities, and you'll need to plan meals carefully to avoid overeating despite reduced hunger signals
Which peptide is most associated with collagen