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1983, New York: Raven Press, 401-417
This study identified a small molecule that activates GSDMD without cleavage, which induces cancer cell pyroptosis and stimulates antitumour immunity
The structure reveals a closed conformation in which the peptide-binding region of the ECD interacts with the extracellular regions of the TMD
Excess consumption of vitamin D can be toxic, leading to marked hypercalcemia, hypercalciuria, and elevated serum 25(OH)D levels
This dosage essentially instructs the body to do something it inherently already does