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And the only drug that really got close, and it really did get very close, and is a reasonable comparison is Trulicity, or Dulaglutide

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Good protein sources include: Lean meats, poultry, and fish Eggs and dairy products Legumes such as lentils, chickpeas, and beans Nuts and seeds Dietary fibre , particularly soluble and fermentable types, promotes GLP-1 secretion through multiple mechanisms

Metabolic Adaptation Works Against You As calories drop: Thyroid signaling can downregulate Energy expenditure decreases Fat oxidation becomes less efficient This is why many patients feel: Cold Tired Weak Stuck despite continued dieting GLP-1 drugs suppress appetite they dont protect metabolism

JAMA Cardiol 10(1):9698 Haddy N, Jourdain H, Desplas D, Bertrand M, Jabagi MJ, Rives-Lange C, Zureik M (2025) Use of semaglutide (Wegovy) in adults in France: A nationwide drug utilization study

Study results showed that those treated with semaglutide (vs placebo) experienced reductions in symptoms and physical limitations, greater improvements in exercise function and greater weight loss