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Kamolz, T., Pointner, R

Iron toxicity mediated by oxidative stress enhances tissue damage in an animal model of diabetes

Within this population: 8,533 individuals were included in the semaglutide versus other glucose-lowering drug comparison (2,397 vs 6,136) 7,455 individuals were included in the semaglutide versus SGLT2 inhibitor comparison (1,650 vs 3,725) Key findings reduced risk of seizures After statistical adjustment, initiation of semaglutide was associated with a lower risk of epilepsy or seizures compared with both comparator groups: Compared with other glucose-lowering drugs: Hazard ratio: 0.46 95% confidence interval: 0.250.83 P = .010 Compared with SGLT2 inhibitors: Hazard ratio: 0.44 95% confidence interval: 0.220.86 P = .017 These findings suggest a meaningful reduction in relative risk among those initiating semaglutide

CE is also a technique well-suited for the rapid analysis of polar metabolites in a wide variety of biological samples by injecting a small amount of samples into a vial (Garcia-Canas et al., 2019)