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Longevity , Cellular damage from oxidative stress, and buildup of toxins in the body can all contribute to ongoing health issues and increase the effects of aging

For example, the mitochondria in their skeletal muscle have become smaller and shorter, while those of white adipose tissue (WAT) are small and elongated, with an irregular crest, and the larger the adipocytes, the less mitochondria are present (7476)

doi:10.1677/jme.0.0080213 PubMed: 1376622 Tomas FM, Lemmey AB, Read LC, Ballard FJ

Oral supplements have a 10% level of bioavailability because they dissolve in the digestive system

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