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This finding, more pronounced in patients with autonomic dysregulation, is interpreted as indicative of increased oxidative stress and therefore may represent an epiphenomenon providing evidence for reverse causality in the UA-PD relationship

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These studies revealed that DSePA was not an efficient GPx mimic and its ability to catalyze the detoxification of hydroperoxides through the GPx cycle was considerably lower than ebselen [82, 83]