glp-1 and dementia mimetics cognition MIND Matters | Quarterly Newsletter

IP mobilizes intracellular calcium stores while DAG activates PKC

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Hansen L, Hartmann B, Bisgaard T, Mineo H, Jorgensen PN, and Holst JJ

In this context, GLP-1RAs can inhibit the secretion of IL-2 and interferon (IFN)-, thereby regulating the immune microenvironment and preventing diabetes [144]

These CVOT findings are supported by a real-world study performed in over 3 million patients with T2DM from the United States, in which patients treated with SGLT2is did not have a higher risk of any or lower amputation compared with incretins or other glucose-lowering agents [77]