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Taken together, the metabolic actions of GLP-1 and glucagon, as well as their structural similarities, inspired the search for single-molecule GLP-1R/GcgR co-agonists as potential candidates for obesity treatment

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Most of these side effects peak during the dose escalation phase, particularly in the first one to two weeks after each dose increase, and then gradually improve as your body adapts

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Nausea is most pronounced during the initial weeks of GLP-1 treatment and typically diminishes significantly after 24 weeks as your body adapts to the medication

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When clinically appropriate, our Chandler providers may prescribe GLP-1 medications including semaglutide and tirzepatide as part of a physician-supervised weight loss program

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If you lose weight while taking Tresiba, your doctor may change your treatment plan

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