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Methods Subjects Thirteen clinically definite ALS patients (12 males and 1 female, mean age 53.9 2.8 years) and seven healthy controls (3 males and 4 females, mean age 57.7 5.7 years) entered our study

Importantly, FOXO4-DRI showed no significant toxicity or impact on viability and apoptosis in normal TM3 Leydig cells, where FOXO4 expression is typically low

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