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In the H 2 O 2 -induced melanocyte model, Hyp protected melanocytes from oxidative damage by regulating the PI3K/Akt pathway, inhibiting p38 phosphorylation and suppressing mitochondrial apoptotic signaling, which included upregulation of the Bcl-2/Bax ratio and expression of Akt, and downregulation of caspase 3, p38 (Yang et al., 2016)
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The role of the cyclin dependent kinase inhibitor p21cip1/waf1 in targeting cancer: molecular mechanisms and novel therapeutics
GHK-Cu talks to your cells at a genetic level, turning on hundreds of pro-repair, pro-regeneration pathways while dialing down pro-inflammatory and tissue-breaking signals
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