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Supplementary Video 1 Partial unbinding and binding simulation of Ex4-l-Ala
n = 7 mice per group
With very few clinical data available, we had to opt for a precision-based sample size calculation rather than a power-based calculation
however, since then, a higher 7.2 mg dose of Wegovy has been approved, with roughly 19% to 21% weight loss in its own trial, and it has not been compared head-to-head with tirzepatide
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