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Despite its natural formulation, Lemon Bottle lacks clinical trial data and regulatory oversight, raising concerns about product consistency and safety
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Immunohistochemistry analysis confirmed the overlapping of hydroxyproline staining with collagen 1A1 (Col1A1) signal in HFD mice, suggesting that the increased activity of P4HA1 might be localized in the area of collagen synthesis (Suppl
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Eggers and Beggs tests were applied to assess funnel plot symmetry quantitatively.29 We also used the CINeMA (Confidence in Network Meta-Analysis) framework to assess the certainty of the evidence in six key areas, including within-study bias, reporting bias, indirectness, imprecision, heterogeneity, and inconsistency.3031 We assessed intransitivity for the CINeMA framework by comparing potential effect modifiers, such as baseline age and HbA 1c concentration, between studies that provided direct and indirect evidence for each comparison
