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This exposure can lead to a range of neurodevelopmental and physical symptoms, including cognitive impairments, developmental delays, autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), and congenital malformations

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[34] [35] [36] Valproate is not commonly used to prevent or treat migraine headaches, but it may be prescribed if other medications are not effective

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These are early signals, but ones that deserve careful attention and have clinical implications for how combination therapy of metformin and GLP-RA is approached in routine practice