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IGF-1 and growth hormone receptor activation controls confirming that AOD-9604 does not engage the classical hGH receptor or elevate IGF-1, distinguishing its mechanism from full-length growth hormone in cell-based reporter systems

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Given that both peptide 15 and peptide 20 are modified forms of GCG (differed by 7 residues), ligand recognition patterns are highly conserved across the three peptides except for a few positions

10.1172/JCI115499 J Clin Invest

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