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In mice, fasting-induced FGF21 signaling leads to PKA-dependent recruitment of a histone demethylase, JMJD3, to the promoters of autophagy genes (157)

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lobata reported its anti-diabetic competency in streptozotocin-induced diabetic rats, in compliance with the fact that the polarity of the organic solvent affects the solubility of bioactive compounds and its antioxidant property, which is supported by in vitro and in vivo generated results (79, 80)