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It is possible that GLP-1R agonists reduce cocaine seeking, in part, by increasing GABA release from presynaptic terminals in the VTA, effects consistent with the post-synaptic mechanism revealed in the current study

Effects of the sigma-1 receptor agonist blarcamesine in a murine model of fragile X syndrome: neurobehavioral phenotypes and receptor occupancy

Pathological or compulsive hair pulling, also known as trichotillomania, is a widespread yet underdiagnosed psychological disorder

With combined activation (CagriSema) the effect does not add linearly, but supra-additively , which is why the combination has a stronger clinical result than either component alone

Wolf E, Hoeflich A, Lahm H

Only the concentration and the corresponding syringe draw change