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Sample selection critically influences research outcomes, with airway-derived specimens like sputum providing non-invasive inflammatory insights (Sagel et al., 2012), while BALF accesses deeper airways despite invasiveness limitations (Gharib et al., 2010

Retinoids still have decades of independent trials behind them

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These side effects are usually mild and go away quickly

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Any diagnostic or therapeutic inference drawn from the group-level GSH reduction therefore remains hypothesis-generating, and would need to be confirmed in larger, independent cohorts using longitudinal designs and ideally more objective indices of disease activity, such as prospective headache diaries or attack-phase measurements