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Large, well-designed Phase II/III RCTs with distinct primary goals, uniform diagnostic criteria, and active comparators are needed
Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy
Notably, Arg1 expression in MDSCs contributes to arginine depletion in the microenvironment, further inhibiting T-cell antitumor function and reducing their survival
In addition, increased IGFBP levels were reported in kidneys from diabetic rats, which may also contribute to increased renal IGF-1 levels [205]
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