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& Zebeli, Q

There was no significant difference between these two treatment strategies overall (HR 0.88, 95% CI 0.68 to 1.14, p = 0.35)

GPs and patients will need clarity on who will provide this support and how these services will be funded. NICE recommendations Semaglutide (up to a maintenance dose of 2.4 mg once weekly) can be used, within its marketing authorisation, alongside a reduced-calorie diet and increased physical activity, as an option for reducing the risk of a major adverse cardiovascular event (that is, cardiovascular death, non-fatal myocardial infarction or non-fatal stroke) in adults with both: established cardiovascular disease (CVD), defined as at least 1 of the following: previous myocardial infarction previous ischaemic or haemorrhagic stroke symptomatic peripheral arterial disease (they have intermittent claudication with an ankle-brachial index of less than 0.85 at rest, or have had a peripheral arterial revascularisation procedure or an amputation because of atherosclerotic disease), and a body mass index (BMI) of at least 27 kg/m2 Source: NICE Listen to our recent podcast episode where Pulse clinical adviser Dr Keith Hopcroft interviews Professor Ahmet Fuat, honorary professor of primary care cardiology at Durham University and GP with extended role in cardiorenal medicine, about the evidence base behind the recommendation, what the roll out might look like, who is eligible, who will be responsible for managing care, and how it fits in with existing NICE guidance on treating patients with type 2 diabetes with SGLT-2 inhibitors

NICE TA924

Increased Appetite Growth hormone stimulates metabolic activity and can increase appetite

You're noting what happens when it happens and what else was going on at the time