how was glp 1 discovered Timeline of GLP-1 discovery and clinical development. (a) Key events in How GLP-1 Drugs Went From

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In previous research, EA at the ST36 acupoint was shown to prevent shrinkage of the prefrontal cortical astrocytes and alleviate depressive-like behavior in mice exposed to CUMS

In obese mice, semaglutide was found to reduce intramuscular fat accumulation and body weight, stimulate protein synthesis in muscle, and promote an increase in the relative proportion of SM

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In the brain, they observed changes in the expression of genes associated with mitochondrial and neuronal structure, mitochondrial respiration, and neurodevelopmental processes, with key genes (e.g., fkbp5 and ucp2 ) correlating with the response to SSRIs and neurodevelopment