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Functional and Clinical Relevance of Novel and Known PCSK1 Variants for Childhood Obesity and Glucose Metabolism. Molecular Metabolism, vol

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Furthermore, when we repeated the meta-analysis excluding ELIXA, the trial done with a short-acting GLP-1 receptor agonist in patients with acute coronary syndrome, the outcome of worsening of kidney function, based predominantly on change in eGFR, was also improved. Sattar and colleagues analyzed data from eight randomized, placebo-controlled trials with 60,080 participants testing injectable or oral GLP-1 receptor agonists in adults with type 2 diabetes, including the recently presented AMPLITUDE-O

That is important, because it confirms that VEGFR2 is not just one of many mechanisms, but truly a causal pathway