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Some people report not feeling as thirsty as before starting treatment, which may contribute to constipation
Doses, indications, and trial designs differ, but the headline pattern is consistent across multiple peer-reviewed analyses: higher GLP-1 dose drives higher GI rates, and adding GIP receptor activity (as tirzepatide does) appears to modestly buffer the diarrhea-specific signal compared to high-dose semaglutide alone
Severe new weakness, numbness, or paralysis in a leg, concern for vascular or neurologic emergency
B12 is included for energy and because it is cheap, well tolerated and gives the injection a perceptible effect though only patients who are actually deficient should expect a real energy change from it
However, consistent dosage over the years may result in considerable cumulative effects
It also depends on how your body responds to the drug
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